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Probing Conformational Changes in Human DNA Topoisomerase IIα by Pulsed Alkylation Mass Spectrometry

Type II topoisomerases are essential enzymes for solving DNA topological problems by passing one segment of DNA duplex through a transient double-strand break in a second segment. The reaction requires the enzyme to precisely control DNA cleavage and gate opening coupled with ATP hydrolysis. Using p...

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Detalhes bibliográficos
Main Authors: Chen, Yu-tsung, Collins, Tammy R. L., Guan, Ziqiang, Chen, Vincent B., Hsieh, Tao-Shih
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408185/
https://ncbi.nlm.nih.gov/pubmed/22679013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377606
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