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The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation

Eukaryotic topoisomerase 2 (Top2) and one of its interacting partners, topoisomerase IIβ binding protein 1 (TopBP1) are two proteins performing essential cellular functions. We mapped the interacting domains of these two proteins using co-immunoprecipitation and pulldown experiments with truncated o...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Chen, Yu-tsung Shane, Wu, Jianhong, Modrich, Paul, Hsieh, Tao-shih
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933235/
https://ncbi.nlm.nih.gov/pubmed/27129233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.721357
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