Phosphorylation of the BRCA1 C Terminus (BRCT) Repeat Inhibitor of hTERT (BRIT1) Protein Coordinates TopBP1 Protein Recruitment and Amplifies Ataxia Telangiectasia-mutated and Rad3-related (ATR) Signaling

The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase functions as a central node in the DNA damage response signaling network. The mechanisms by which ATR activity is amplified and/or maintained are not understood. Here we demonstrate that BRIT1/microcephalin (MCPH1), a human disease-rela...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhang, Bo, Wang, Edward, Dai, Hui, Shen, Jianfeng, Hsieh, Hui-Ju, Lu, Xiongbin, Peng, Guang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256359/
https://ncbi.nlm.nih.gov/pubmed/25301947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.587113
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