An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers.

The antisense activity and gene specificity of two classes of oligonucleotides (ONs) were directly compared in a highly controlled assay. One class of ONs has been proposed to act by targeting the degradation of specific RNAs through an RNase H-mediated mechanism and consists of C-5 propynyl pyrimid...

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Päätekijät: Bonham, M A, Brown, S, Boyd, A L, Brown, P H, Bruckenstein, D A, Hanvey, J C, Thomson, S A, Pipe, A, Hassman, F, Bisi, J E
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1995
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC306831/
https://ncbi.nlm.nih.gov/pubmed/7537874
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