A carregar...
RNase H is responsible for the non-specific inhibition of in vitro translation by 2'-O-alkyl chimeric oligonucleotides: high affinity or selectivity, a dilemma to design antisense oligomers.
Ribonuclease H (RNase H) which recognizes and cleaves the RNA strand of mismatched RNA-DNA heteroduplexes can induce non-specific effects of antisense oligonucleotides. In a previous paper [Larrouy et al. (1992), Gene, 121, 189-194], we demonstrated that ODN1, a phosphodiester 15mer targeted to the...
Na minha lista:
| Main Authors: | , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1995
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307221/ https://ncbi.nlm.nih.gov/pubmed/7567453 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|