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Tyrosine 27 of the specificity polypeptide of EcoKI can be UV crosslinked to a bromodeoxyuridine-substituted DNA target sequence.

The specificity (S) subunit of the restriction enzyme EcoKI imparts specificity for the sequence AAC(N6)GTGC. Substitution of thymine with bromodeoxyuridine in a 25 bp DNA duplex containing this sequence stimulated UV light-induced covalent crosslinking to the S subunit. Crosslinking occurred only a...

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Bibliografski detalji
Glavni autori: Chen, A, Powell, L M, Dryden, D T, Murray, N E, Brown, T
Format: Artigo
Jezik:Inglês
Izdano: 1995
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC306828/
https://ncbi.nlm.nih.gov/pubmed/7739896
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