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Sequence context of antisense RelA/NF-kappa B phosphorothioates determines specificity.

The use of antisense oligomers to achieve inhibition of gene expression is complicated by frequent non-specific effects, and even the control oligomers often exhibit sequence-specific effects. We have recently shown that in diverse tumor-derived cell lines, a 24mer phosphorothioate oligomer antisens...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Maltese, J Y, Sharma, H W, Vassilev, L, Narayanan, R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 1995
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306823/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7739892/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.7.1146
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