Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

Nuclear factor-kappaB (NF-κB) p50/RelA is a key molecule with a dual effect in the progression of ischemic stroke. In harmful ischemia, but not in preconditioning insult, neurotoxic activation of p50/RelA is characterized by RelA-specific acetylation at Lys310 (K310) and deacetylation at other Lys r...

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Detalhes bibliográficos

Principais autores:	Annamaria Lanzillotta, Giuseppe Pignataro, Caterina Branca, Ornella Cuomo, Ilenia Sarnico, Marina Benarese, Lucio Annunziato, PierFranco Spano, Marina Pizzi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2013-01-01
Colecção:	Neurobiology of Disease
Assuntos:	RelA acetylation MCAO OGD HDAC inhibitors
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996112003051
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