Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2

BACKGROUND: RNA interference (RNAi) screens have been used to identify novel components of signal-transduction pathways in a variety of organisms. We performed a small interfering (si)RNA screen for novel members of the transforming growth factor (TGF)-β pathway in a human keratinocyte cell line. Th...

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Autori principali: Schultz, Nikolaus, Marenstein, Dina R, De Angelis, Dino A, Wang, Wei-Qing, Nelander, Sven, Jacobsen, Anders, Marks, Debora S, Massagué, Joan, Sander, Chris
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068080/
https://ncbi.nlm.nih.gov/pubmed/21401928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1758-907X-2-3
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