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A modified single-strand annealing model best explains the joining of DNA double-strand breaks mammalian cells and cell extracts.
The joining of DNA double-strand breaks in vivo is frequently accompanied by the loss of a few nucleotides at the junction between the interacting partners. In vitro systems mimic this loss and, on detailed analysis, have suggested two models for the mechanism of end-joining. One invokes the use of...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1995
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC306802/ https://ncbi.nlm.nih.gov/pubmed/7731791 |
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