Roscovitine Inhibits EBNA1 Serine 393 Phosphorylation, Nuclear Localization, Transcription, and Episome Maintenance

Latent Epstein-Barr virus (EBV) infection causes human lymphomas and carcinomas. EBV usually persists as an episome in malignant cells. EBV episome persistence, replication, and gene expression are dependent on EBNA1 binding to multiple cognate sites in oriP. To search for inhibitors of EBNA1- and o...

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Bibliografische gegevens
Hoofdauteurs: Kang, Myung-Soo, Lee, Eun Kyung, Soni, Vishal, Lewis, Timothy A., Koehler, Angela N., Srinivasan, Viswanathan, Kieff, Elliott
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2011
Onderwerpen:
Genome Replication and Regulation of Viral Gene Expression
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067954/
https://ncbi.nlm.nih.gov/pubmed/21209116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01628-10
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