Roscovitine Inhibits EBNA1 Serine 393 Phosphorylation, Nuclear Localization, Transcription, and Episome Maintenance

Latent Epstein-Barr virus (EBV) infection causes human lymphomas and carcinomas. EBV usually persists as an episome in malignant cells. EBV episome persistence, replication, and gene expression are dependent on EBNA1 binding to multiple cognate sites in oriP. To search for inhibitors of EBNA1- and o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kang, Myung-Soo, Lee, Eun Kyung, Soni, Vishal, Lewis, Timothy A., Koehler, Angela N., Srinivasan, Viswanathan, Kieff, Elliott
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2011
Gaiak:
Genome Replication and Regulation of Viral Gene Expression
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067954/
https://ncbi.nlm.nih.gov/pubmed/21209116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01628-10
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