A Single Amino Acid in EBNA-2 Determines Superior B Lymphoblastoid Cell Line Growth Maintenance by Epstein-Barr Virus Type 1 EBNA-2

Sequence differences in the EBNA-2 protein mediate the superior ability of type 1 Epstein-Barr virus (EBV) to transform human B cells into lymphoblastoid cell lines compared to that of type 2 EBV. Here we show that changing a single amino acid (S442D) from serine in type 2 EBNA-2 to the aspartate fo...

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Detalhes bibliográficos
Main Authors: Tzellos, Stelios, Correia, Paulo B., Karstegl, Claudio Elgueta, Cancian, Laila, Cano-Flanagan, Julian, McClellan, Michael J., West, Michelle J., Farrell, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136291/
https://ncbi.nlm.nih.gov/pubmed/24850736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01000-14
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