Increased association between Epstein-Barr virus EBNA2 from type 2 strains and the transcriptional repressor BS69 restricts EBNA2 activity

Natural variation separates Epstein-Barr virus (EBV) into type 1 and type 2 strains. Type 2 EBV is less transforming in vitro due to sequence differences in the EBV transcription factor EBNA2. This correlates with reduced activation of the EBV oncogene LMP1 and some cell genes. Transcriptional activ...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Ponnusamy, Rajesh, Khatri, Ritika, Correia, Paulo B., Wood, C. David, Mancini, Erika J., Farrell, Paul J., West, Michelle J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6638984/
https://ncbi.nlm.nih.gov/pubmed/31283782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007458
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