Requirement for the Amino-Terminal Domain of Sindbis Virus nsP4 during Virus Infection

The Sindbis virus RNA-dependent RNA polymerase nsP4 possesses an amino-terminal region that is unique to alphaviruses and is predicted to be disordered. To determine the importance of this region during alphavirus replication, 29 mutations were introduced, and resultant viruses were assessed for gro...

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Bibliografiske detaljer
Main Authors: Rupp, Jonathan C., Jundt, Natasha, Hardy, Richard W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067876/
https://ncbi.nlm.nih.gov/pubmed/21248049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02058-10
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