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Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotics.

The proposition that the 2-amino group of guanine plays a critical role in determining how antibiotics recognise their binding sites in DNA has been tested by relocating it, using tyrT DNA derivative molecules substituted with inosine plus 2,6-diaminopurine (DAP). Irrespective of their mode of inter...

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Sonraí Bibleagrafaíochta
Main Authors: Bailly, C, Waring, M J
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1995
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC306781/
https://ncbi.nlm.nih.gov/pubmed/7731800
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