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Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotics.
The proposition that the 2-amino group of guanine plays a critical role in determining how antibiotics recognise their binding sites in DNA has been tested by relocating it, using tyrT DNA derivative molecules substituted with inosine plus 2,6-diaminopurine (DAP). Irrespective of their mode of inter...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1995
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC306781/ https://ncbi.nlm.nih.gov/pubmed/7731800 |
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