Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotics.
The proposition that the 2-amino group of guanine plays a critical role in determining how antibiotics recognise their binding sites in DNA has been tested by relocating it, using tyrT DNA derivative molecules substituted with inosine plus 2,6-diaminopurine (DAP). Irrespective of their mode of inter...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1995
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306781/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731800/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.6.885 |
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