Serotype-Specific Inactivation of the Cellular DNA Damage Response during Adenovirus Infection

Adenovirus type 5 (Ad5) inactivates the host cell DNA damage response by facilitating the degradation of Mre11, DNA ligase IV, and p53. In the case of p53, this is achieved through polyubiquitylation by Ad5E1B55K and Ad5E4orf6, which recruit a Cul5-based E3 ubiquitin ligase. Recent evidence indicate...

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Main Authors: Forrester, Natalie A., Sedgwick, Garry G., Thomas, Anoushka, Blackford, Andrew N., Speiseder, Thomas, Dobner, Thomas, Byrd, Philip J., Stewart, Grant S., Turnell, Andrew S., Grand, Roger J. A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2011
主題:
Virus-Cell Interactions
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067775/
https://ncbi.nlm.nih.gov/pubmed/21159879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01748-10
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