Rapid Detection of Fluoroquinolone-Resistant and Heteroresistant Mycobacterium tuberculosis by Use of Sloppy Molecular Beacons and Dual Melting-Temperature Codes in a Real-Time PCR Assay

Fluoroquinolones (FQ) are important second-line drugs to treat tuberculosis; however, FQ resistance is an emerging problem. Resistance has been mainly attributed to mutations in a 21-bp region of the Mycobacterium tuberculosis gyrA gene, often called the quinolone resistance-determining region (QRDR...

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Detalhes bibliográficos
Main Authors: Chakravorty, Soumitesh, Aladegbami, Bola, Thoms, Kimberley, Lee, Jong Seok, Lee, Eun Gae, Rajan, Vignesh, Cho, Eun-Jin, Kim, Hyunchul, Kwak, Hyunkyung, Kurepina, Natalia, Cho, Sang-Nae, Kreiswirth, Barry, Via, Laura E., Barry, Clifton E., Alland, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Mycobacteriology and Aerobic Actinomycetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067712/
https://ncbi.nlm.nih.gov/pubmed/21191047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.02271-10
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