Genotypic Susceptibility Testing of Mycobacterium tuberculosis Isolates for Amikacin and Kanamycin Resistance by Use of a Rapid Sloppy Molecular Beacon-Based Assay Identifies More Cases of Low-Level Drug Resistance than Phenotypic Lowenstein-Jensen Testing

Resistance to amikacin (AMK) and kanamycin (KAN) in clinical Mycobacterium tuberculosis strains is largely determined by specific mutations in the rrs gene and eis gene promoter. We developed a rapid, multiplexed sloppy molecular beacon (SMB) assay to identify these mutations and then evaluated assa...

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Detalhes bibliográficos
Publicado no:J Clin Microbiol
Main Authors: Chakravorty, Soumitesh, Lee, Jong Seok, Cho, Eun Jin, Roh, Sandy S., Smith, Laura E., Lee, Jiim, Kim, Cheon Tae, Via, Laura E., Cho, Sang-Nae, Barry, Clifton E., Alland, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mycobacteriology and Aerobic Actinomycetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290905/
https://ncbi.nlm.nih.gov/pubmed/25339395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.02059-14
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