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Different Substrate Recognition Requirements for Cleavage of Synaptobrevin-2 by Clostridium baratii and Clostridium botulinum Type F Neurotoxins

Botulinum neurotoxins (BoNTs) cause botulism, which can be fatal if it is untreated. BoNTs cleave proteins necessary for nerve transmission, resulting in paralysis. The in vivo protein target has been reported for all seven serotypes of BoNT, i.e., serotypes A to G. Knowledge of the cleavage sites h...

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Bibliografski detalji
Glavni autori: Kalb, Suzanne R., Baudys, Jakub, Egan, Christina, Smith, Theresa J., Smith, Leonard A., Pirkle, James L., Barr, John R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067225/
https://ncbi.nlm.nih.gov/pubmed/21169446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01662-10
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