Different Substrate Recognition Requirements for Cleavage of Synaptobrevin-2 by Clostridium baratii and Clostridium botulinum Type F Neurotoxins

Botulinum neurotoxins (BoNTs) cause botulism, which can be fatal if it is untreated. BoNTs cleave proteins necessary for nerve transmission, resulting in paralysis. The in vivo protein target has been reported for all seven serotypes of BoNT, i.e., serotypes A to G. Knowledge of the cleavage sites h...

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Библиографические подробности
Главные авторы: Kalb, Suzanne R., Baudys, Jakub, Egan, Christina, Smith, Theresa J., Smith, Leonard A., Pirkle, James L., Barr, John R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2011
Предметы:
Enzymology and Protein Engineering
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067225/
https://ncbi.nlm.nih.gov/pubmed/21169446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01662-10
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