Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome

Anthrax lethal toxin (LT) is the major virulence factor for Bacillus anthracis. The lethal factor (LF) component of this bipartite toxin is a protease which, when transported into the cellular cytoplasm, cleaves mitogen-activated protein kinase kinase (MEK) family proteins and induces rapid toxicity...

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Bibliografiske detaljer
Main Authors: Newman, Zachary L., Sirianni, Nicole, Mawhinney, Christina, Lee, Margaret S., Leppla, Stephen H., Moayeri, Mahtab, Johansen, Lisa M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067098/
https://ncbi.nlm.nih.gov/pubmed/21149629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00772-10
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