Increased Glycolytic ATP Synthesis Is Associated with Tafenoquine Resistance in Leishmania major

Tafenoquine (TFQ), an 8-aminoquinoline used to treat and prevent Plasmodium infections, could represent an alternative therapy for leishmaniasis. Indeed, TFQ has shown significant leishmanicidal activity both in vitro and in vivo, where it targets Leishmania mitochondria and activates a final apopto...

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Hlavní autoři: Manzano, José Ignacio, Carvalho, Luis, Pérez-Victoria, José M., Castanys, Santiago, Gamarro, Francisco
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067095/
https://ncbi.nlm.nih.gov/pubmed/21199921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01545-10
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