Stabilization of double-stranded oligonucleotides using backbone-linked disulfide bridges.
A convenient, practical route to the synthesis of disulfide-bridged oligonucleotides has been developed. Aliphatic linkers with terminal thiol groups have been attached to the phosphodiester backbones of partially or fully complementary oligonucleotide sequences and oxidized to yield covalently clos...
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| Publicado no: | Nucleic Acids Res |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306667/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.2.285 |
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