Stabilization of double-stranded oligonucleotides using backbone-linked disulfide bridges.

A convenient, practical route to the synthesis of disulfide-bridged oligonucleotides has been developed. Aliphatic linkers with terminal thiol groups have been attached to the phosphodiester backbones of partially or fully complementary oligonucleotide sequences and oxidized to yield covalently clos...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Gao, H, Yang, M, Cook, A F
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 1995
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306667/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.2.285
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