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Role of Water in Mediating the Assembly of Alzheimer Amyloid-β Aβ16–22 Protofilaments
The role of water in promoting the formation of protofilaments (the basic building blocks of amyloid fibrils) is investigated using fully atomic molecular dynamics simulations. Our model protofilament consists of two parallel β-sheets of Alzheimer Amyloid-β 16–22 peptides (Ac-K(16)-L(17)-V(18)-F(19)...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3066469/ https://ncbi.nlm.nih.gov/pubmed/18661994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8017303 |
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