Role of Water in Mediating the Assembly of Alzheimer Amyloid-β Aβ16–22 Protofilaments

The role of water in promoting the formation of protofilaments (the basic building blocks of amyloid fibrils) is investigated using fully atomic molecular dynamics simulations. Our model protofilament consists of two parallel β-sheets of Alzheimer Amyloid-β 16–22 peptides (Ac-K(16)-L(17)-V(18)-F(19)...

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Bibliographic Details
Main Authors: Krone, Mary Griffin, Hua, Lan, Soto, Patricia, Zhou, Ruhong, Berne, B. J., Shea, Joan-Emma
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066469/
https://ncbi.nlm.nih.gov/pubmed/18661994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8017303
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