A rare variant in MYH6 is associated with high risk of sick sinus syndrome

Through complementary application of SNP genotyping, whole-genome sequencing and imputation in 38,384 Icelanders, we have discovered a previously unidentified sick sinus syndrome susceptibility gene, MYH6, encoding the alpha heavy chain subunit of cardiac myosin. A missense variant in this gene, c.2...

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Главные авторы: Holm, Hilma, Gudbjartsson, Daniel F, Sulem, Patrick, Masson, Gisli, Helgadottir, Hafdis Th, Zanon, Carlo, Magnusson, Olafur Th, Helgason, Agnar, Saemundsdottir, Jona, Gylfason, Arnaldur, Stefansdottir, Hrafnhildur, Gretarsdottir, Solveig, Matthiasson, Stefan E, Thorgeirsson, Guðmundur, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Stefansson, Hreinn, Werge, Thomas, Rafnar, Thorunn, Kiemeney, Lambertus A, Parvez, Babar, Muhammad, Raafia, Roden, Dan M, Darbar, Dawood, Thorleifsson, Gudmar, Walters, G Bragi, Kong, Augustine, Thorsteinsdottir, Unnur, Arnar, David O, Stefansson, Kari
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066272/
https://ncbi.nlm.nih.gov/pubmed/21378987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.781
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