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An AlphaScreen™ Based High-throughput Screen to Identify Inhibitors of Hsp90 and Cochaperone Interaction

Hsp90 has emerged as an important anti-cancer drug target because of its essential role in promoting the folding and maturation of many oncogenic proteins. Here we describe the development of the first high throughput screen, based on AlphaScreen™ technology, to identify a novel type of Hsp90 inhibi...

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מידע ביבליוגרפי
Main Authors: Yi, Fang, Zhu, Pingjun, Southall, Noel, Inglese, James, Austin, Christopher P, Zheng, Wei, Regan, Lynne
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066041/
https://ncbi.nlm.nih.gov/pubmed/19211782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057108330114
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