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Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a multi-functional DNA-binding protein that plays important roles in tumorigenesis and adipogenesis. Previous results showed that HMGA2 is a potential therapeutic target of anticancer and anti-obesity drugs by inhibiting its DNA-binding...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7606612/ https://ncbi.nlm.nih.gov/pubmed/33139812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75890-0 |
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