Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays

The mammalian high mobility group protein AT-hook 2 (HMGA2) is a multi-functional DNA-binding protein that plays important roles in tumorigenesis and adipogenesis. Previous results showed that HMGA2 is a potential therapeutic target of anticancer and anti-obesity drugs by inhibiting its DNA-binding...

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Publicat a:Sci Rep
Autors principals: Su, Linjia, Bryan, Nadezda, Battista, Sabrina, Freitas, Juliano, Garabedian, Alyssa, D’Alessio, Federica, Romano, Miriam, Falanga, Fabiana, Fusco, Alfredo, Kos, Lidia, Chambers, Jeremy, Fernandez-Lima, Francisco, Chapagain, Prem P., Vasile, Stefan, Smith, Layton, Leng, Fenfei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606612/
https://ncbi.nlm.nih.gov/pubmed/33139812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75890-0
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