New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis

A series of novel bichalcone analogs were synthesized and evaluated in lipopolysaccharide (LPS)-activated microglial cells as inhibitors of nitric oxide (NO) and for in vitro anticancer activity using a limited panel of four human cancer cell lines. All analogs inhibited NO production. Compounds 4 a...

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Bibliografiske detaljer
Main Authors:	Vijaya Bhaskar Reddy, M., Shen, Yuh-Chiang, Hwang, Tsong-Long, Bastow, Kenneth F., Qian, Keduo, Lee, Kuo-Hsiung, Wu, Tian-Shung
Format:	Artigo
Sprog:	Inglês
Udgivet:	2011
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3066007/ https://ncbi.nlm.nih.gov/pubmed/21377368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.02.004
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New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis

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