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Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations
Multidrug resistance is a serious problem in current chemotherapy. The efflux system largely responsible for resistance in Escherichia coli contains the drug transporter, AcrB. The structures of AcrB were solved in 2002 as the symmetric homo-trimer, and then in 2006 as the asymmetric homo-trimer. Th...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3065909/ https://ncbi.nlm.nih.gov/pubmed/21081915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1116 |
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