The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

Activation Induced cytidine Deaminase (AID) initiates Immunoglobulin (Ig) heavy chain (IgH) class switch recombination (CSR) and Ig variable region somatic hypermutation (SHM) in B lymphocytes by deaminating cytidines on template and non-template strands of transcribed DNA substrates. However, the m...

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Bibliografiske detaljer
Main Authors: Basu, Uttiya, Meng, Fei-Long, Keim, Celia, Grinstein, Veronika, Pefanis, Evangelos, Eccleston, Jennifer, Zhang, Tingting, Myers, Darienne, Wesemann, Duane R., Januszyk, Kurt, Gregory, Richard I., Deng, Haiteng, Lima, Christopher D., Alt, Frederick W.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065114/
https://ncbi.nlm.nih.gov/pubmed/21255825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.01.001
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