A molecular basis for the exquisite CD1d-restricted Antigen-specificity and functional responses of Natural Killer T cells

Natural Killer T (NKT) cells respond to a variety of CD1d-restricted antigens (Ags), although the basis for Ag discrimination by the NKT cell receptor (TCR) is unclear. Here we describe NKT TCR fine specificity against several closely related Ags, termed altered glycolipid ligands (AGLs), which diff...

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Autori principali: Wun, Kwok S., Cameron, Garth, Patel, Onisha, Pang, Siew Siew, Pellicci, Daniel G., Sullivan, Lucy C., Keshipeddy, Santosh, Young, Mary H., Uldrich, Adam P., Thakur, Meena S., Richardson, Stewart K., Howell, Amy R., Illarionov, Petr A., Brooks, Andrew G., Besra, Gurdyal S., McCluskey, James, Gapin, Laurent, Porcelli, Steven A., Godfrey, Dale I., Rossjohn, Jamie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064745/
https://ncbi.nlm.nih.gov/pubmed/21376639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.02.001
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