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Inhibitors of the Oncogenic Transcription Factor AP-1 from Podocarpus latifolius

An activator protein-1 (AP-1) based bioassay guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3) along with three known norditerpenes (4–6). Compounds 4 and 6 were responsi...

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Detalhes bibliográficos
Main Authors: Devkota, Krishna P., Ratnayake, Ranjala, Colburn, Nancy H., Wilson, Jennifer A., Henrich, Curtis J., McMahon, James B., Beutler, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064712/
https://ncbi.nlm.nih.gov/pubmed/21306129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np100736y
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