Quassinoid Inhibition of AP-1 Function Does Not Correlate with Cytotoxicity or Protein Synthesis Inhibition

Several quassinoids were identified in a high-throughput screening assay as inhibitors of the transcription factor AP-1. Further biological characterization revealed that while their effect was not specific to AP-1, protein synthesis inhibition and cell growth assays were inconsistent with a mechani...

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Detalhes bibliográficos
Main Authors: Beutler, John A., Kang, Moon-Il, Robert, Francis, Clement, Jason A., Pelletier, Jerry, Colburn, Nancy H., McKee, Tawnya C., Goncharova, Ekaterina, McMahon, James B., Henrich, Curtis J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837105/
https://ncbi.nlm.nih.gov/pubmed/19199792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np800732n
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