Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression

AIMS: To investigate the adaptations of left ventricular function and calcium handling to chronic heart rate reduction with ivabradine in the reperfused heart. METHODS AND RESULTS: Rabbits underwent 20-min coronary artery occlusion followed by 3 weeks of reperfusion. Throughout reperfusion, rabbits...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Couvreur, Nicolas, Tissier, Renaud, Pons, Sandrine, Chetboul, Valérie, Gouni, Vassiliky, Bruneval, Patrick, Mandet, Chantal, Pouchelon, Jean-Louis, Berdeaux, Alain, Ghaleh, Bijan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064678/
https://ncbi.nlm.nih.gov/pubmed/20028694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehp554
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky