Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression

AIMS: To investigate the adaptations of left ventricular function and calcium handling to chronic heart rate reduction with ivabradine in the reperfused heart. METHODS AND RESULTS: Rabbits underwent 20-min coronary artery occlusion followed by 3 weeks of reperfusion. Throughout reperfusion, rabbits...

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Main Authors: Couvreur, Nicolas, Tissier, Renaud, Pons, Sandrine, Chetboul, Valérie, Gouni, Vassiliky, Bruneval, Patrick, Mandet, Chantal, Pouchelon, Jean-Louis, Berdeaux, Alain, Ghaleh, Bijan
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064678/
https://ncbi.nlm.nih.gov/pubmed/20028694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehp554
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