Antitumor Agents 283. Further Elaboration of Desmosdumotin C Analogs as Potent Antitumor Agents: Activation of Spindle Assembly Checkpoint as Possible Mode of Action

In our ongoing study of the desmosdumotin C (1) series, twelve new analogues, 21–32, mainly with structural modifications in ring-A, were prepared and evaluated for in vitro antiproliferative activity against several human tumor cell lines. Among them, the 4′-iodo-3,3,5-tripropyl-4-methoxy analogue...

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Détails bibliographiques
Auteurs principaux: Nakagawa-Goto, Kyoko, Wu, Pei-Chi, Bastow, Kenneth F., Yang, Shuenn-Chen, Yu, Sung-Liang, Chen, Hsuan-Yu, Lin, Jau-Chen, Goto, Masuo, Morris-Natschke, Susan L., Yang, Pan-Chyr, Lee, Kuo-Hsiung
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064560/
https://ncbi.nlm.nih.gov/pubmed/21296579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.01.001
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