Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase

Sustained and complete inhibition of HER3 and its output to PI3K/Akt are required for the optimal antitumor effect of therapeutic inhibitors of the HER2 oncogene. Here, we show that, after inhibition of the HER2 tyrosine kinase with lapatinib, there is PI3K/Akt and FoxO3a-dependent up-regulation of...

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Bibliographic Details
Main Authors: Garrett, Joan T., Olivares, María Graciela, Rinehart, Cammie, Granja-Ingram, Nara D., Sánchez, Violeta, Chakrabarty, Anindita, Dave, Bhuvanesh, Cook, Rebecca S., Pao, William, McKinely, Eliot, Manning, H. C., Chang, Jenny, Arteaga, Carlos L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064360/
https://ncbi.nlm.nih.gov/pubmed/21385943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016140108
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