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Tissue-specific expression of the human alpha 1-antitrypsin gene is controlled by multiple cis-regulatory elements.

Human alpha 1-antitrypsin (AAT) is expressed in the liver, and a 318 bp fragment immediately flanking the CAP site of the gene was found to be sufficient to drive the expression of a reporter gene (CAT) specifically in hepatoma cells. The enhancing activity however, was orientation-dependent. The DN...

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Udgivet i:Nucleic Acids Res
Principais autores: Shen, R F, Li, Y, Sifers, R N, Wang, H, Hardick, C, Tsai, S Y, Woo, S L
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1987
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306367/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2823229/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/15.20.8399
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