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Non-viral systemic delivery of siRNA or antisense oligonucleotides targeted to Jun N-terminal kinase 1 prevents cellular hypoxic damage

Many pathological conditions and environmental impacts lead to the development of severe tissue hypoxia that aggravates the primary disorder, provokes cell death, and limits the patient’s recovery. We hypothesized that suppression of Jun N-terminal kinase 1 (JNK1) will limit tissue damage induced by...

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Detalles Bibliográficos
Main Authors: Betigeri, Seema, Zhang, Min, Garbuzenko, Olga, Minko, Tamara
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063508/
https://ncbi.nlm.nih.gov/pubmed/21461383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-010-0003-1
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