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Highly Activated Cytotoxic CD8 T Cells Express Protective IL-10 At The Peak Of Coronavirus-induced Encephalitis

Acute viral encephalitis requires rapid pathogen elimination without significant bystander tissue damage. Here, we show that IL-10, a potent anti-inflammatory cytokine, is produced transiently at the peak of infection by CD8 T cells in the brains of coronavirus-infected mice. IL-10(+)CD8 and IL-10(−...

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Detalhes bibliográficos
Main Authors: Trandem, Kathryn, Zhao, Jingxian, Fleming, Erica, Perlman, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063297/
https://ncbi.nlm.nih.gov/pubmed/21317392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003292
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