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Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus
Mice infected with the neurotropic JHM strain of mouse hepatitis virus (JHMV) develop acute and chronic demyelinating diseases with histopathological similarities to MS. The process of demyelination is largely immune-mediated, as immunodeficient mice (RAG1(−/−) mice) do not develop demyelination upo...
Bewaard in:
| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851486/ https://ncbi.nlm.nih.gov/pubmed/20208000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903918 |
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