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Virally Expressed Interleukin-10 Ameliorates Acute Encephalomyelitis and Chronic Demyelination in Coronavirus-Infected Mice

The absence of interleukin-10 (IL-10), a potent anti-inflammatory cytokine results in increased immune-mediated demyelination in mice infected with a neurotropic coronavirus (recombinant J2.2-V-1 [rJ2.2]). Here, we examined the therapeutic effects of increased levels of IL-10 at early times after in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Trandem, Kathryn, Jin, Qiushuang, Weiss, Kayla A., James, Britnie R., Zhao, Jingxian, Perlman, Stanley
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126551/
https://ncbi.nlm.nih.gov/pubmed/21593179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00510-11
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