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EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: A potential mechanism of EGFR-driven antagonism of apoptosis

BACKGROUND: Epidermal growth factor receptor (EGFR) plays an essential role in normal development, tumorigenesis and malignant biology of human cancers, and is known to undergo intracellular trafficking to subcellular organelles. Although several studies have shown that EGFR translocates into the mi...

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Main Authors: Cao, Xinyu, Zhu, Hu, Ali-Osman, Francis, Lo, Hui-Wen
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063231/
https://ncbi.nlm.nih.gov/pubmed/21388543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-26
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