Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-[alpha]-thymidylate covalently linked to an azidoproflavine derivative.

A 3-azidoproflavine derivative was covalently linked to the 5'-end of an octathymidylate synthesized with the [alpha]-anomers of the nucleoside. Two target nucleic acids were used for this substituted oligo-[alpha]-thymidylate: a 27-mer single-stranded DNA fragment containing an octadeoxyadenyl...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Le Doan, T, Perrouault, L, Praseuth, D, Habhoub, N, Decout, J L, Thuong, N T, Lhomme, J, Hélène, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 1987
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306305/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3671065/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/15.19.7749
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