CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies

Antibody-dependent cell-mediated cytotoxicity (ADCC), which is largely mediated by natural killer (NK) cells, is thought to play an important role in the efficacy of rituximab, an anti-CD20 monoclonal antibody (mAb) used to treat patients with B-cell lymphomas. CD137 is a costimulatory molecule expr...

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Библиографические подробности
Главные авторы: Kohrt, Holbrook E., Houot, Roch, Goldstein, Matthew J., Weiskopf, Kipp, Alizadeh, Ash A., Brody, Josh, Müller, Antonia, Pachynski, Russell, Czerwinski, Debra, Coutre, Steven, Chao, Mark P., Chen, Lieping, Tedder, Thomas F., Levy, Ronald
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2011
Предметы:
Lymphoid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062409/
https://ncbi.nlm.nih.gov/pubmed/21193697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-301945
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