CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies

Antibody-dependent cell-mediated cytotoxicity (ADCC), which is largely mediated by natural killer (NK) cells, is thought to play an important role in the efficacy of rituximab, an anti-CD20 monoclonal antibody (mAb) used to treat patients with B-cell lymphomas. CD137 is a costimulatory molecule expr...

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Detalhes bibliográficos
Main Authors: Kohrt, Holbrook E., Houot, Roch, Goldstein, Matthew J., Weiskopf, Kipp, Alizadeh, Ash A., Brody, Josh, Müller, Antonia, Pachynski, Russell, Czerwinski, Debra, Coutre, Steven, Chao, Mark P., Chen, Lieping, Tedder, Thomas F., Levy, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062409/
https://ncbi.nlm.nih.gov/pubmed/21193697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-301945
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